Specialty Areas:

• Thoracic Oncology
• Stereotactic body radiation therapy

Patients Seen At:

• Siteman Cancer Center
  Center for Advanced Medicine
  4921 Parkview Place, Floor LL
  St. Louis, MO 63110
  (314) 747-7236

Mailing Address:

• Siteman Cancer Center
  Center for Advanced Medicine
  4921 Parkview Place, Floor LL
  St. Louis, MO 63110

Areas of Clinical Interest:

• Radiation oncology
• Lung cancer
• Esophagus cancer
• Stereotactic body radiation therapy
• Applications of PET imaging for radiation therapy
• Proton Therapy

Board Certification:

• Radiation Oncology--Certified

Medical Education:

• Medical Degree: University of Arkansas, 1993
• Residency: Department of Radiation and Cellular Oncology, The University of Chicago Medical Center, 1994-1998
• Fellowship: American Society of Therapeutic Radiology and Oncology, Department of Radiation and Cellular Oncology, The University of Chicago Medical Center, 1998

Hospital Affiliations:

• Barnes-Jewish Hospital

Major or Recent Publications/Awards

Honors and Awards:

• European Society of Therapeutic Radiology and Oncology Young Investigator
  Travel Award, 2001
• Radiation Oncology Teacher of the Year, 1999 and 2008
• Awarded the ASTRO Basic Science Research Fellowship Award, 1997
• Radiologic Society of North America Roentgen Resident/Fellow Research Award, 1997
• Alpha Omega Alpha Medical Honor Society, 1993
• Executive Committee, Radiation Therapy Oncology Group, 2005
• Honorary Member, Chicago Radiological Society, 2005.
• S. Lee Kling Endowed Chair in Radiation Oncology 2009
  

Selected Publications:

• Bradley JD, Ieumwananonthachai N, Purdy JA, Wasserman TH, Lockett MA, Graham MV, Perez, CA, Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small cell lung carcinoma.  Int J Radiat Oncol Biol Phys 2002; 52(1):49-57.
• Bradley JD, Scott C, Paris K, Demas W, Machtay M, Komaki R, Movsas B, Rubin P, Sause W, A Phase III Comparison of Radiation Therapy With or Without Recombinant b-Interferon for Poor-Risk Patients with Locally Advanced Non-Small Cell Lung Cancer (RTOG 93-04). Int J Radiat Oncol Biol Phys 2002; 52:1173-1179.
• Singh AK, Lockett MA, Bradley JD, Predictors of radiation-induced esophageal toxicity in patients with non small cell lung cancer treated with three dimensional conformal radiation therapy.  Int J Radiat Oncol Biol Phys 2003; 55(2):337-341.
• Bradley JD, Wahab S, Lockett MA, Perez CA, Purdy JA, Elective Nodal Failures Are Uncommon in Medically Inoperable Patients with Stage I Non-small Cell Lung Carcinoma Treated with Limited Radiotherapy Fields. Int J Radiat Oncol Biol Phys 2003; 56(2): 342-347.
• Dehdashti F, Mintun MA, Lewis JS, Bradley J, Govindan R, Laforest R, Welch MJ, Siegel BA, In Vivo Assessment of Tumor Hypoxia in Lung Cancer  with (60)Cu-ATSM. Journal of Nuclear Medicine 2003; 30:1130-1134.
• Low DA, Dempsey JF, Bradley JD, Christensen G, Politte D, Nystrom M, Kalinin E, Parikh P, Mutic S, Wahab S, Islam T, Whiting BR, A Method for the Four-Dimensional Measurement of Normal and Cancerous Lung During Free Breathing.  Medical Physics 2003; 30(6), 1254-1263.
• Bradley JD, Deasy J, Bentzen SM, El Naqa I: Dosimetric Correlates for Acute Esophagitis in Patients Treated for Lung Carcinoma.  Int J Radiat Oncol Biol Phys 2004; 58(4);1106-1113.
• Bradley JD, Thorstad WL, Mutic S, Miller TR, Dehdashti F, Siegel BA, Bosch W, Bertrand R, Impact of FDG-PET on Radiation Therapy Volume in Non-Small Cell Lung Cancer.  Int J Radiat Oncol Biol Phys 2004; 59(1):78‑86.
• Bradley JD, Dehdashti F, Mintun MA, Govindan R, Trinkhaus K, Siegel BA, Positron Emission Tomography in Limited-Stage Small Cell Lung Cancer; A Prospective Study.  Journal of Clinical Oncology 2004; 22(16):3248-3254.
• Bradley JD, Perez CA, Dehdashti F, Siegel BA, Implementing Biological
  Target Volumes in Radiation Treatment Planning for Non-Small Cell Lung Cancer.  Journal of Nuclear Medicine 2004; 45(1 suppl):96S-101S.
• Bradley JD and Movsas B, Radiation Esophagitis: Predictive factors and preventative strategies.  Seminars in Radiation Oncology 2004; 14(4):280-286.
• Bradley JD, Graham MV, Winter K, Purdy JA, Komaki R, Roa WH, Ryu JK, Bosch W, Emami B, Toxicity and Outcome Results of RTOG 9311: a Phase I/II Dose Escalation Study Using 3D Conformal Radiation Therapy in Patients with Inoperable Non-Small Cell Lung Carcinoma.  Int J Radiat Oncol Biol Phys 2005; 61(2): 318-328.
• Krupnick AS, Kreisel D, Hope A, Bradley J, Govindan R, Meyers B. Recent Advances and Future Perspectives in the Management of Lung Cancer. Current Problems in Surgery 2005; 42(8):548-610.
• Bradley JD, Paulus R, Graham MV Ettinger DS, Johnstone D, Pilepich M, Machtay M, Komaki R, Atkins J, Curran WJ, Scott C. RTOG 9705, A phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIA non-small cell lung cancer (NSCLC) patients - promising long term survival results.  Journal of Clinical Oncology 2005; 23(15): 3480-3487.
• Bradley JD. Radiation Dose Escalation for Non-Small Cell Lung Cancer Within the Radiation Therapy Oncology Group (RTOG). Seminars in Oncology 32(2 suppl 3); 111S-113S, 2005.
• Bradley J and Movsas B. Radiation pneumonitis and esophagitis in thoracic irradiation. Cancer Treat Res 2006; 128:43-64.
• Hope AJ, Lindsay PE, El Naqa I, Alaly JR, Vicic M, Bradley JD, Deasy JO. Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters. International Journal of Radiation Oncology Physics, 2006; 65(1):112-124.
• Ajani JA, Winter K, Okawara GS, Donohue JH, Pisters PW, Crane CH, Greskovich JF, Anne PR, Bradley JD, Willett C, Rich TA. A Radiation Therapy Oncology Group Phase II Trial of Preoperative Chemoradiation in Patients with Localized Gastric Adenocarcinoma (RTOG 9904): Quality of Combined Modality Therapy and Pathologic Response.  Journal of Clinical Oncology, 2006; 24(24):3953-3958.
• El Naqa I, Bradley J, Blanco AI, Lindsay PE, Vicic M, hope A, Deasy JO. Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors. Int J Radiat Oncol Biol Phys, 2006; 64(4):1275-1286.
• Biehl K, Kong FM, Dehdashti F, Jin JY, Mutic S, El Naqa I, Siegel BA, Bradley JD. 18F-FDG PET definition of gross tumor volume for radiotherapy of non-small cell lung cancer: Is a single standardized uptake value threshold approach appropriate? J Nucl Med 2006; 47(11): 1808-1812.
• Bradley J. Radiographic response and clinical toxicity following SBRT for stage I lung cancer. Journal of Thoracic Oncology 2007; 2(7 Suppl 3): S118-24.
• Biehl K and Bradley J. 18F-FDG PET in planning radiation treatment of non small cell lung cancer: Where exactly is the tumor? J Nuclear Medicine 2007; 48(8):1403.
• Bradley JD, Hope AJ, El Naqa, Apte A, Lindsay PE, Bosch W, Matthews J, Sause W, Graham MV, and Deasy JO. A nomogram to predict radiation pneumonitis, derived from a combined analysis of RTOG 9311 and institutional data. Int J Radiat Oncol Biol Phys, 2007; 69(4): 985-992.
• Werner-Wasik M, Swann RS, Bradley J, Graham M, Emami B, Purdy J, Sause W. Increasing tumor volume is predictive of poor overall and progression-free survival: Secondary analysis of the Radiation Therapy Oncology Group 93-11 Phase I-II radiation dose-escalation study in patients with inoperable non-small cell lung cancer. Int J Radiat Oncol Biol Phys 2008;70(2):385-90.
• Santhanam L, Malinowski K, Hubenschmidt j, Dimmer S, Mayse ML, Bradley J, Chaudhari A, Lechleiter K, Goddu SK, Esthappan J, Mutic S, Low DA, Parikh P.  Fiducial-based translational localization accuracy of electromagnetic tracking system and on-board kilovoltage imaging system. Int J Radiat Oncol Biol Phys 2008; 70(3):892-899.
• Trovo M, Bradley JD, El Naqa I, Foster E, Meyers B, Govindan R, Patterson GA.  Esophageal carcinoma with celiac nodal metastases; Curative or palliative?  Journal of Thoracic Oncology 2008; 3(7):751-5.
• Mayse ML, Parikh PJ, Lechlieter KM, Dimmer S, Park M, Chaudari A, Talcott M, Low DA, and Bradley JD.  Bronchoscopic implantation of a novel wireless electromagnetic transponder in the canine lung: A feasibility study. Int J Radiat Oncol Biol Phys 2008; 72(1):93-98.
• Ajani JA, Winter K, Okawara GS, Donohue JH, Pisters PW, Crane CH, Greskovich JF, Anne PR, Bradley JD, Willett C, Rich TA.  A Radiation Therapy Oncology Group randomized Phase II Trial of Two Chemoradiotherapy Regimens for Locally-Advanced Carcinoma of the Esophagus.  Journal of Clinical Oncology 2008;26(28):4551-6.
• Trovo M, Linda A, Javidan-Nejad C, El Naqa I, and Bradley J.  Early and Late Radiographic Changes Following Stereotactic Radiation Therapy for Lung Cancer. Lung Cancer, 2009
• Rosenzweig KE, Movsas B, Bradley J, Gewanter RM, Gopal RS, Komaki RU, Kong FM, Lee HK, Feins RH, Langer CJ. ACR appropriateness criteria on nonsurgical treatment for non-small-cell lung cancer: poor performance status or palliative intent. J Am Cooll Radiol 2009;6(2):85-95
• Bradley JD, Moughan J, Graham MV, Byhardt, R, Govindan R, Fowler J, Purdy JA, Michalski JM, Gore E, Choy H.  A phase I/II dose escalaltion study with concurrent chemotherapy for patients with inoperable stages I-III non-small cell lung cancer: The phase I results of RTOG 0117.  Int J Radiat Oncol Biol Phys 2008.